Title of article
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors
Author/Authors
Katrin Groebke Zbinden، نويسنده , , David W. Banner، نويسنده , , Jean Ackermann، نويسنده , , Allan D’Arcy، نويسنده , , Daniel Kirchhofer، نويسنده , , Yu-Hua Ji، نويسنده , , Thomas B. Tschopp، نويسنده , , Sabine Wallbaum، نويسنده , , Lutz Weber، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
817
To page
822
Abstract
Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795294
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