Title of article
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
Author/Authors
Zhijian Zhao، نويسنده , , William H. Leister، نويسنده , , Ronald G. Robinson، نويسنده , , Stanley F. Barnett، نويسنده , , Deborah Defeo-Jones، نويسنده , , Raymond E. Jones، نويسنده , , George D. Hartman، نويسنده , , Joel R. Huff، نويسنده , , Hans E. Huber، نويسنده , , Mark E. Duggan، نويسنده , , Craig W. Lindsley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
905
To page
909
Abstract
This letter describes the discovery of a novel series of dual Akt1/Akt2 kinase inhibitors, based on a 2,3,5-trisubstituted pyridine scaffold. Compounds from this series, which contain a 5-tetrazolyl moiety, exhibit more potent inhibition of Akt2 than Akt1.
Keywords
kinase , pyridine , tetrazole , inhibitor , Akt
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795307
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