Author/Authors :
Timothy A. Lewis، نويسنده , , Lynn Bayless، نويسنده , , Alan J. Dipesa، نويسنده , , Joseph B. Eckman، نويسنده , , Michel Gillard، نويسنده , , Lyn Libertine، نويسنده , , Ralph T. Scannell، نويسنده , , Donna M. Wypij، نويسنده , , Michelle A. Young، نويسنده ,
Abstract :
A series of N-hydroxycarbamates containing a histaminergic H1 receptor antagonist pharmacophore was synthesized. In vitro assays determined the compounds had both histaminergic binding and 5-lipoxygenase inhibiting activities comparable to the corresponding N-hydroxyurea analog. Animal models demonstrated antihistaminergic and the 5-lipopxygenase inhibitory activity, with the N-hydroxyurea analog having a better overall profile.
