Author/Authors :
Lucjan Strekowski، نويسنده , , Maryam Hojjat، نويسنده , , Ewa Wolinska، نويسنده , , Alesia N. Parker، نويسنده , , Ekaterina Paliakov، نويسنده , , Tadeusz Gorecki، نويسنده , , Farial A. Tanious، نويسنده , , W.David Wilson، نويسنده ,
Abstract :
Several substituted quinolin-4-amines and heteroaromatic analogs were synthesized and evaluated for interaction with triplex polydA•2polydT and duplex polydA•polydT by using UV-thermal melting experiments. Excellent triple-helix DNA ligands with high affinity toward T•A•T triplets and triple/duplex selectivity were designed through a rational approach.
