Title of article
Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors
Author/Authors
Yongxin Han، نويسنده , , André Giroux، نويسنده , , John Colucci، نويسنده , , Christopher I. Bayly، نويسنده , , Daniel J. McKay، نويسنده , , Anne Sophie Roy ، نويسنده , , Steve Xanthoudakis، نويسنده , , John Vaillancourt، نويسنده , , Dita M. Rasper، نويسنده , , John Tam، نويسنده , , Paul Tawa، نويسنده , , Donald W. Nicholson، نويسنده , , Robert J. Zamboni، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
8
From page
1173
To page
1180
Abstract
The iterative process for the discovery of a series of pyrazinone mono-amides as potent, selective and reversible non-peptide caspase-3 inhibitors (e.g., M826 and M867) is reported. These compounds display potent anti apoptotic activities in a number of cell based systems in vitro as well as in several animal models in vivo.
Keywords
Pyrazinone mono-amide , Caspase-3 inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795359
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