Title of article
Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action
Author/Authors
Jens Pohlmann، نويسنده , , Thomas Lampe، نويسنده , , Mitsuyuki Shimada، نويسنده , , Peter G. Nell، نويسنده , , Josef Pernerstorfer، نويسنده , , Niels Svenstrup، نويسنده , , Nina A. Brunner، نويسنده , , Guido Schiffer، نويسنده , , Christoph Freiberg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
1189
To page
1192
Abstract
The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis. Structure–activity relationship (SAR) studies revealed a high degree of variability for the fatty acid side chain, allowing optimization of physicochemical parameters, and a restricted SAR for the pyrrolidinedione group, indicating major relevance of this subunit for efficient target binding.
Keywords
Pyrrolidine diones , Moiramide B , Andrimid , Acetyl-CoA carboxylase , antibiotic
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795362
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