Title of article
Discovery and structure–activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists
Author/Authors
Wu Yang، نويسنده , , Yufeng Wang، نويسنده , , Jacques Y. Roberge، نويسنده , , Zhengping Ma، نويسنده , , Yalei Liu، نويسنده , , R. Michael Lawrence، نويسنده , , David P. Rotella، نويسنده , , Ramakrishna Seethala، نويسنده , , Jean H.M Feyen، نويسنده , , John K. Dickson Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
1225
To page
1228
Abstract
A structure–activity relationship study of the amine portion of the calcilytic compound NPS-2143 resulted in the discovery of substituted 2-benzylpyrrolidines as replacements for the 1,1-dimethyl-2-naphthalen-2-yl-ethylamine. When compared to NPS-2143, a newly discovered compound, 3h, exhibited similar potency as a calcium-sensing receptor (CaR) antagonist and a superior human ether-a-go-go related gene (hERG) profile.
Keywords
Calcium-sensing receptor antagonist , Osteoporosis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795370
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