Title of article
Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors
Author/Authors
Jin-Hee Ahn، نويسنده , , Jin Ah Kim، نويسنده , , Hye-Min Kim، نويسنده , , Hyuk-Man Kwon، نويسنده , , Sun-Chul Huh، نويسنده , , Sang Dal Rhee، نويسنده , , Kwang Rok Kim، نويسنده , , Sung-Don Yang، نويسنده , , Sung-Dae Park، نويسنده , , Jae-Mok Lee، نويسنده , , Sung-Soo Kim، نويسنده , , Hyae Gyeong Cheon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
1337
To page
1340
Abstract
A new series of pyrazolidine derivatives was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 9i was the most active in this series, exhibited IC50 value of 1.56 μM and ED50 value of 80 mg/kg (in vivo DP-IV inhibition; po).
Keywords
Dipeptidyl peptidase IV , DP-IV , Pyrazolidine , Anti-diabetic agent
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795391
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