Author/Authors :
Jin-Hee Ahn، نويسنده , , Jin Ah Kim، نويسنده , , Hye-Min Kim، نويسنده , , Hyuk-Man Kwon، نويسنده , , Sun-Chul Huh، نويسنده , , Sang Dal Rhee، نويسنده , , Kwang Rok Kim، نويسنده , , Sung-Don Yang، نويسنده , , Sung-Dae Park، نويسنده , , Jae-Mok Lee، نويسنده , , Sung-Soo Kim، نويسنده , , Hyae Gyeong Cheon، نويسنده ,
Abstract :
A new series of pyrazolidine derivatives was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 9i was the most active in this series, exhibited IC50 value of 1.56 μM and ED50 value of 80 mg/kg (in vivo DP-IV inhibition; po).
Keywords :
Dipeptidyl peptidase IV , DP-IV , Pyrazolidine , Anti-diabetic agent
