Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors
Author/Authors :
Bin Chen، نويسنده , , Pavel A. Petukhov، نويسنده , , Mira Jung، نويسنده , , Alfredo Velena، نويسنده , , Elena Eliseeva، نويسنده , , Anatoly Dritschilo، نويسنده , , Alan P. Kozikowski، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
4
From page :
1389
To page :
1392
Abstract :
A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.
