Author/Authors :
Ping Zhou، نويسنده , , Yinfa Yan، نويسنده , , Ronald Bernotas، نويسنده , , Boyd L. Harrison، نويسنده , , Donna Huryn، نويسنده , , Albert J. Robichaud، نويسنده , , Guo Ming Zhang، نويسنده , , Deborah L. Smith، نويسنده , , Lee E. Schechter، نويسنده ,
Abstract :
The preparation of a novel class of 4-(2-aminoethoxy)-N-(phenylsulfonyl)indoles which exhibit high affinity towards the 5-HT6 receptor is reported here. Among these compounds, 4-(2-methylaminoethoxy)-N-(phenylsulfonyl)indole 5g showed superior affinity (Ki = 1 nM) towards the 5-HT6 receptor as well as excellent selectivity (>2000-fold) against the closely related subtype 5-HT7 receptor.
