Title of article
Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors
Author/Authors
Jason Z. Vlahakis، نويسنده , , Robert T. Kinobe، نويسنده , , Raymond J. Bowers، نويسنده , , James F. Brien، نويسنده , , Kanji Nakatsu، نويسنده , , Walter A. Szarek، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
1457
To page
1461
Abstract
Several analogues based on the lead structure of azalanstat were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). A number of these compounds, which are structurally distinct from metalloporphyrin HO inhibitors, were found to be selective for the HO-1 isozyme (stress induced), and had substantially less inhibitory activity on HO-2, the constitutive isozyme.
Keywords
Selective inhibitors , Heme , carbon monoxide , Azalanstat , Heme oxygenase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795415
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