Author/Authors :
Lawrence G. Hamann، نويسنده , , J. Hoyt Meyer، نويسنده , , Daniel A. Ruppar، نويسنده , , Keith B. Marschke، نويسنده , , Francisco J. Lopez، نويسنده , , Elizabeth A. Allegretto، نويسنده , , Donald S. Karanewsky، نويسنده ,
Abstract :
An oxabicyclic template for estrogen receptor α and β agonists has been identified which can be tuned to provide moderate levels of selectivity for either receptor sub-type. Structure–activity relationships within this phenol-substituted oxabicyclo[3.3.1]nonene series are described. Select compounds from the present series showed activity in vivo after oral dosing in rodent models of uterine proliferation.
