Author/Authors :
Per Sauerberg، نويسنده , , John P. Mogensen، نويسنده , , Lone Jeppesen، نويسنده , , L. Anders Svensson، نويسنده , , Jan Fleckner، نويسنده , , Jan Nehlin، نويسنده , , Erik M. Wulff، نويسنده , , Ingrid Pettersson ، نويسنده ,
Abstract :
A series of dimeric PPAR agonists were designed and tested for PPAR activity in vitro. The SAR showed that dimeric ligands with a common group or full dimeric ligands had retained or even increased PPARγ potency. The dimeric agonist concept can be used to fine tune the subtype selectivity of PPAR agonists. The PPARγ potency could, at least partly, be explained using molecular modeling.
