Title of article :
iPF2α-III-17,18,19,20-d4: Total synthesis and metabolism
Author/Authors :
Seongjin Kim، نويسنده , , William S. Powell، نويسنده , , John A. Lawson، نويسنده , , Sheila H. Jacobo، نويسنده , , Domenico Pratico، نويسنده , , Garret A. FitzGerald، نويسنده , , Kirk Maxey، نويسنده , , Joshua Rokach، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The first total synthesis of 17,18,19,20-d4-iPF2α-III 32, a deuterated analog of iPF2α-III, is described. We have used this analog in some β-oxidation studies with rat liver homogenates and have shown that 32 was metabolized to 17,18,19,20-tetradeutero-2,3-dinor-iPF2α-III 36 and 17,18,19,20-tetradeutero-2,3-dinor-5,6-dihydro-iPF2α-III 37.
Keywords :
Dinor-dihydro-iPF2?-III , metabolism , arachidonic acid , iPF2?-III , Dinor-iPF2?-III , d4-iPF2?-III
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
