Title of article
Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors
Author/Authors
Arie Zask، نويسنده , , Joshua Kaplan، نويسنده , , Xuemei Du، نويسنده , , Gloria MacEwan، نويسنده , , Vincent Sandanayaka، نويسنده , , Nancy Eudy، نويسنده , , Jeremy Levin، نويسنده , , Guixian Jin، نويسنده , , Jun Xu، نويسنده , , Terri Cummons، نويسنده , , Dauphine Barone، نويسنده , , Semiramis Ayral-Kaloustian، نويسنده , , Jerauld Skotnicki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
1641
To page
1645
Abstract
Potent and selective TACE and MMP inhibitors utilizing the diazepine and thiazepine ring systems were synthesized and evaluated for biological activity in in vitro and in vivo models of TNF-α release. Oral activity in the mouse LPS model of TNF-α release was seen. Efficacy in the mouse collagen induced arthritis model was achieved with diazepine 20.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795452
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