• Title of article

    Novel heterocyclic thyromimetics

  • Author/Authors

    Helmut Haning، نويسنده , , Michael Woltering، نويسنده , , Ulrich Mueller، نويسنده , , Gunter Schmidt، نويسنده , , Carsten Schmeck، نويسنده , , Verena Voehringer، نويسنده , , Axel Kretschmer، نويسنده , , Josef Pernerstorfer، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    6
  • From page
    1835
  • To page
    1840
  • Abstract
    Novel heterocycle-fused thyromimetics are presented carrying indoles or indazoles instead of the phenolic group in T3. Potent agonists were identified in both series. SAR trends are examined and found to be mostly consistent with previously published thyromimetics. Moderate THRβ selectivity (approx. 10-fold) was observed in the indole series using isoform-selective transient THR transfection assays
  • Keywords
    Thyromimetics , indazoles , indoles
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2005
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    795488

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=795488