Title of article
Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain
Author/Authors
Pengchang P. Shao، نويسنده , , Dong-Ok Kim، نويسنده , , Michael H. Fisher، نويسنده , , Maria L. Garcia، نويسنده , , Gregory J. Kaczorowski، نويسنده , , Chunshi Li، نويسنده , , Kathryn A. Lyons، نويسنده , , William J. Martin، نويسنده , , Peter T. Meinke، نويسنده , , Birgit T. Priest، نويسنده , , McHardy M. Smith، نويسنده , , Matthew J. Wyvratt Jr.، نويسنده , , Feng Ye، نويسنده , , William H. Parsons، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
7
From page
1901
To page
1907
Abstract
A series of new voltage-gated sodium channel blockers were prepared based on the screening lead succinic diamide BPBTS. Replacement of the succinimide linker with the more rigid cyclic 1,2-trans-diamide linker was well tolerated. N-Methylation on the biphenylsulfonamide side of the amide moiety significantly reduced the clearance rate in rat pharmacokinetic studies.
Keywords
Sodium channel blocker , Chronic pain , Neuropathic pain
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795501
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