Title of article
6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists
Author/Authors
Eugenia Kiselgof، نويسنده , , Deen B. Tulshian، نويسنده , , Leyla Arik، نويسنده , , Hongtao Zhang، نويسنده , , Ahmad Fawzi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2119
To page
2122
Abstract
Structure–activity relationships have been investigated through substitutions at the 9-position of the 2-amino-6-(2-furanyl) purine (5) to identify novel and selective A2A adenosine receptor antagonists. Several potent and selective antagonists were identified. In particular, compounds 20, 25, and 26 show very high affinity with excellent selectivity.
Keywords
9-H Purin , Antagonist , Adenosine receptor , 2-Furanyl
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795544
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