Title of article :
DNA photocleavage and biological activity of a pyrene dihydrodioxin
Author/Authors :
Eric T. Mack، نويسنده , , Dagne Birzniece، نويسنده , , Darren R. Veach، نويسنده , , William Coyle، نويسنده , , R. Marshall Wilson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the X 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
