Title of article
DNA photocleavage and biological activity of a pyrene dihydrodioxin
Author/Authors
Eric T. Mack، نويسنده , , Dagne Birzniece، نويسنده , , Darren R. Veach، نويسنده , , William Coyle، نويسنده , , R. Marshall Wilson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2173
To page
2176
Abstract
A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the X 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.
Keywords
Photocleavage
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795554
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