Title of article :
Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain
Author/Authors :
D. Ian Paterson، نويسنده , , Dirk Menche، نويسنده , , Anders E. H?kansson، نويسنده , , Adrian Longstaff، نويسنده , , David Wong، نويسنده , , Isabel Barasoain، نويسنده , , Rubén M. Buey، نويسنده , , J. Fernando D?az، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).
Keywords :
Laulimalide , analogues , Anticancer agent , Nozaki–Kishi coupling , Modelling
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
