Author/Authors :
Brad O. Buckman، نويسنده , , Yuo-Ling Chou، نويسنده , , Meg McCarrick، نويسنده , , Amy Liang، نويسنده , , Dao Lentz، نويسنده , , Raju Mohan، نويسنده , , Michael M. Morrissey، نويسنده , , Kenneth J. Shaw، نويسنده , , Lan Trinh، نويسنده , , David R. Light، نويسنده ,
Abstract :
Reductive amination followed by acylation of polymer-linked formyl aryl amidines generate combinatorial libraries of aryl amidines 8–13. Potent small molecule naphthylamidine inhibitors 12 (Ki < 100 nM) of FVIIa/TF have been discovered and their activity against other serine proteases in the coagulation cascade is reported.
