• Title of article

    Oximinoarylsulfonamides as potent HIV protease inhibitors

  • Author/Authors

    Clinton M. Yeung، نويسنده , , Larry L. Klein، نويسنده , , Charles A. Flentge، نويسنده , , John T. Randolph، نويسنده , , Chen Zhao، نويسنده , , MingHua Sun، نويسنده , , Tatyana Dekhtyar، نويسنده , , Vincent S. Stoll، نويسنده , , Dale J. Kempf، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    4
  • From page
    2275
  • To page
    2278
  • Abstract
    The need for a potent HIV protease inhibitor (PI) to combat emerging PI-resistant viruses is anticipated. Analogs formulated from the combination of structural fragments of Ritonavir, Lopinavir, and Amprenavir were synthesized. Analogs containing the oxime pharmacophore were found to have improved activities against both wild type and resistant (A17) viruses. The synthesis and structure–activity relationships (SAR) based upon the in vitro IC50 of this series of compounds are reported.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2005
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    795572

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=795572