Author/Authors :
Paola Barraja، نويسنده , , Laura Sciabica، نويسنده , , Patrizia Diana، نويسنده , , Antonino Lauria، نويسنده , , Alessandra Montalbano، نويسنده , , Anna Maria Almerico، نويسنده , , Gaetano Dattolo، نويسنده , , Girolamo Cirrincione، نويسنده , , Silvia Disar?، نويسنده , , Giuseppe Basso، نويسنده , , Giampietro Viola، نويسنده , , Francesco Dall’Acqua، نويسنده ,
Abstract :
A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.
