Title of article
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors
Author/Authors
Noel A. Powell، نويسنده , , Emma H. Clay، نويسنده , , Daniel D. Holsworth، نويسنده , , John W. Bryant، نويسنده , , MICHAEL J. RYAN، نويسنده , , Mehran Jalaie، نويسنده , , Erli Zhang، نويسنده , , Jeremy J. Edmunds، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2371
To page
2374
Abstract
We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.
Keywords
renin inhibitor , Ketopiperazine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795591
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