Title of article
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase
Author/Authors
Nuria Tamayo، نويسنده , , Lillian Liao، نويسنده , , Martin Goldberg، نويسنده , , David Powers، نويسنده , , Yan-Yan Tudor، نويسنده , , Violeta Yu، نويسنده , , Lu Min Wong، نويسنده , , Bradley Henkle، نويسنده , , Scot Middleton، نويسنده , , Rashid Syed، نويسنده , , Timothy Harvey، نويسنده , , Graham Jang، نويسنده , , Randall Hungate، نويسنده , , Celia Dominguez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
2409
To page
2413
Abstract
Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition of LPS-induced TNF-α production in mice and exhibited good efficacy in the rat collagen induced arthritis model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795599
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