Prenylated chalcones isolated from Crotalaria genus inhibits in vitro growth of the human malaria parasite Plasmodium falciparum

A prenylated chalcone 2 named crotaorixin, has been isolated from the aerial parts of the Crotalaria orixensis. Its structure has been established by extensive 1D and 2D NMR measurements. In vitro antimalarial activity of crotaorixin as well as few prenylated chalcones isolated from C. medicagenia and C. ramosissima were evaluated at three concentrations (50, 10 and 2 μg/ml) against Plasmodium falciparum (Strain NF-54). Compound 3 has exhibited 100% inhibition of schizont maturation at 2 μg/ml concentration.