Title of article
Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics
Author/Authors
Benjamin K. Ayida، نويسنده , , Klaus B. Simonsen، نويسنده , , Dionisios Vourloumis، نويسنده , , Thomas Hermann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2457
To page
2460
Abstract
Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the dehydroalanine side chain of the macrocyclic antibiotic thiostrepton that acts on the bacterial ribosome.
Keywords
Dehydroalanine , ribosome , Thiostrepton , antibiotics , translation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795606
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