Title of article
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides
Author/Authors
Emanuela Sperlinga، نويسنده , , Piotr Kosson، نويسنده , , Zofia Urbanczyk-Lipkowska، نويسنده , , Giuseppe Ronsisvalle، نويسنده , , Daniel B. Carr، نويسنده , , Andrzej W. Lipkowski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
2467
To page
2469
Abstract
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (6Htc) has been proposed as a rigid mimic of tyrosine conformation in opioid ligand–receptor complex. The significant receptor binding to mu and delta opioid receptors of respective analogues of deltorphin, dermorphin, and endomorphin with d,l-6Htc prove initial prediction.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795608
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