Author/Authors :
Carlo Ballatore، نويسنده , , Simon E. Aspland، نويسنده , , Rosario Castillo، نويسنده , , Joel Desharnais، نويسنده , , Trisha Eustaquio، نويسنده , , Chengzao Sun، نويسنده , , Angelo J. Castellino، نويسنده , , Amos B. Smith III، نويسنده ,
Abstract :
A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2′-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules.
