Title of article
Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers
Author/Authors
Zhiqiang Guo، نويسنده , , Yongsheng Chen، نويسنده , , Charles Q. Huang، نويسنده , , Timothy D. Gross، نويسنده , , Joseph Pontillo، نويسنده , , Martin W. Rowbottom، نويسنده , , John Saunders، نويسنده , , R. Scott Struthers، نويسنده , , Fabio C. Tucci، نويسنده , , Qiu Xie، نويسنده , , Warren Wade، نويسنده , , Yun-Fei Zhu، نويسنده , , Dongpei Wu، نويسنده , , Chen Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2519
To page
2522
Abstract
Uracil derivatives were designed and synthesized to avoid atropisomers observed in the 6-methyluracils as antagonists of the human GnRH receptor. Optimization at the 1- and 5-positions of the uracil resulted in potent compounds such as 24 (Ki = 0.45 nM).
Keywords
Atropisomer , Uracil , Antagonist , GNRH
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795618
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