Title of article :
Synthesis and biological evaluation of gemcitabine–lipid conjugate (NEO6002)
Author/Authors :
Shoukath M. Ali، نويسنده , , Abdul R. Khan، نويسنده , , Moghis U. Ahmad، نويسنده , , Paul Chen، نويسنده , , Saifuddin Sheikh، نويسنده , , Imran Ahmad، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A novel gemcitabine–lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar®.
Keywords :
Gemcitabine , cardiolipin , Lipid–nucleoside conjugate , prodrug
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
