Title of article :
Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity
Author/Authors :
Rômulo P. Ten?rio، نويسنده , , Cristiane S. Carvalho، نويسنده , , Carla S. Pessanha، نويسنده , , José G. de Lima، نويسنده , , Antônio R. de Faria، نويسنده , , Antônio J. Alves، نويسنده , , Edésio J.T. de Melo، نويسنده , , Alexandre J.S. G?es، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.
Keywords :
4-Thiazolidinones , Toxoplasma gondii , thiosemicarbazones
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
