Title of article
Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer
Author/Authors
Takashi Takahashi، نويسنده , , Kazuoki Nakai، نويسنده , , Takayuki Doi، نويسنده , , Masa Yasunaga، نويسنده , , Hiroshi Nakagawa، نويسنده , , Toshihisa Ishikawa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
2601
To page
2605
Abstract
We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.
Keywords
Multidrug resistance reversal agents
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795635
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