Title of article
Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines and their conjugates by azido reductive cyclization strategy as potential DNA-binding agents
Author/Authors
Ahmed Kamal، نويسنده , , A. Hari Babu، نويسنده , , A. Venkata Ramana، نويسنده , , K. Venkata Ramana، نويسنده , , E. Vijaya Bharathi، نويسنده , , M. Shiva Kumar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
2621
To page
2623
Abstract
Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines via azido reductive cyclization process employing FeCl3–NaI reagent system. This methodology has been extended for the preparation of new nicotinamido-pyrrolobenzodiazepine hybrids linked through piperazino-alkane-oxy spacers that exhibit good DNA binding affinity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795639
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