Author/Authors :
Kristi Leonard، نويسنده , , Wenxi Pan، نويسنده , , Beth Anaclerio، نويسنده , , Joan M. Gushue، نويسنده , , Zihong Guo، نويسنده , , Renee L. DesJarlais، نويسنده , , Marge A. Chaikin، نويسنده , , Jennifer Lattanze، نويسنده , , Carl Crysler، نويسنده , , Carl L. Manthey، نويسنده , , Bruce E. Tomczuk، نويسنده , , Juan Jose Marugan، نويسنده ,
Abstract :
We describe the synthesis and structure/activity relationship of RGD mimetics that are potent inhibitors of the integrin αvβ3. Indol-1-yl propionic acids containing a variety of basic moieties at the 5-position, as well as substitutions alpha and beta to the carboxy terminus were synthesized and evaluated. Novel compounds with improved potency have been identified.
