Title of article
Non-peptidic αvβ3 antagonists containing indol-1-yl propionic acids
Author/Authors
Kristi Leonard، نويسنده , , Wenxi Pan، نويسنده , , Beth Anaclerio، نويسنده , , Joan M. Gushue، نويسنده , , Zihong Guo، نويسنده , , Renee L. DesJarlais، نويسنده , , Marge A. Chaikin، نويسنده , , Jennifer Lattanze، نويسنده , , Carl Crysler، نويسنده , , Carl L. Manthey، نويسنده , , Bruce E. Tomczuk، نويسنده , , Juan Jose Marugan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
2679
To page
2684
Abstract
We describe the synthesis and structure/activity relationship of RGD mimetics that are potent inhibitors of the integrin αvβ3. Indol-1-yl propionic acids containing a variety of basic moieties at the 5-position, as well as substitutions alpha and beta to the carboxy terminus were synthesized and evaluated. Novel compounds with improved potency have been identified.
Keywords
RGD mimetic , ?v?3 antagonists , Integrins
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795651
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