Author/Authors :
Suni M. Mustafa، نويسنده , , Supriya A. Bavadekar، نويسنده , , Guoyi Ma، نويسنده , , Bob M. Moore II، نويسنده , , Dennis R. Feller، نويسنده , , Duane D. Miller، نويسنده ,
Abstract :
A series of yohimbine derivatives was synthesized and evaluated for binding affinity at the human α2C-adrenergic receptors expressed in Chinese hamster ovary cells. It has been found that compound 5 shows a higher affinity for α2C-AR than the parent compound yohimbine 1, thereby illustrating that the nature of the linkers affect binding potencies on these receptors.
