Design, synthesis, and evaluation of proline based melanocortin receptor ligands
Author/Authors :
Xinrong Tian، نويسنده , , Timothy Field، نويسنده , , Adam W. Mazur، نويسنده , , Frank H. Ebetino، نويسنده , , John A. Wos، نويسنده , , Doreen Crossdoersen، نويسنده , , Beth B. Pinney، نويسنده , , Russell J. Sheldon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
5
From page :
2819
To page :
2823
Abstract :
A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors.
