Author/Authors :
Stefan Tasler، نويسنده , , Jürgen Kraus، نويسنده , , Stefano Pegoraro، نويسنده , , Andrea Aschenbrenner، نويسنده , , Elena Poggesi، نويسنده , , Rodolfo Testa، نويسنده , , Gianni Motta، نويسنده , , Amedeo Leonardi، نويسنده ,
Abstract :
Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan® technology, a new lead series was identified and further structurally investigated. Ki’s as low as around 100 nM were achieved.
Keywords :
metabotropic glutamate receptor , Molecular modeling , non-competitive antagonist , Neuroplasticity
