Title of article
Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators
Author/Authors
Qinggang Ji، نويسنده , , Jie Gao، نويسنده , , Junbo Wang، نويسنده , , Chunhao Yang، نويسنده , , Xin Hui، نويسنده , , Xueming Yan، نويسنده , , Xihan Wu، نويسنده , , Yuyuan Xie، نويسنده , , Mingwei Wang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
2891
To page
2893
Abstract
A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ERα and ERβ) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice.
Keywords
SERM , 2-b]indole , estrogen receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795692
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