Author/Authors :
Peter C. de Visser، نويسنده , , Peter A.V. van Hooft، نويسنده , , Anne-Marij de Vries، نويسنده , , Ad de Jong، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Herman S. Overkleeft، نويسنده , , Daan Noort، نويسنده ,
Abstract :
An array of analogues of the cationic antimicrobial peptide drosocin was synthesized containing substitutions of Tyr6 and Ser7 in order to increase the proteolytic stability. Stabilizing the N-terminus with unnatural amino acids increased the serum stability of analogues by almost a factor 30 over an 8 h period.
