Title of article
Biological evaluation of Tyr6 and Ser7 modified drosocin analogues
Author/Authors
Peter C. de Visser، نويسنده , , Peter A.V. van Hooft، نويسنده , , Anne-Marij de Vries، نويسنده , , Ad de Jong، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Herman S. Overkleeft، نويسنده , , Daan Noort، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2902
To page
2905
Abstract
An array of analogues of the cationic antimicrobial peptide drosocin was synthesized containing substitutions of Tyr6 and Ser7 in order to increase the proteolytic stability. Stabilizing the N-terminus with unnatural amino acids increased the serum stability of analogues by almost a factor 30 over an 8 h period.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795695
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