Author/Authors :
Stefania Storelli، نويسنده , , Pauline Verdijk، نويسنده , , Dennis Verzijl، نويسنده , , Henk Timmerman، نويسنده , , Andrea C. van de Stolpe، نويسنده , , Cornelis P. Tensen، نويسنده , , Martine J. Smit، نويسنده , , Iwan J.P. De Esch، نويسنده , , Rob Leurs، نويسنده ,
Abstract :
A series of 3-phenyl-3H-quinazolin-4-ones have been synthesized and tested for affinity and activity at the chemokine CXCR3 receptor. The most potent compound (1d) has been evaluated using radioligand binding and calcium mobilization assays and is considered a useful tool for further characterization of the CXCR3 receptor.
Keywords :
Chemokine , CXCR3 , synthesis , SAR
