Title of article
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors
Author/Authors
Sunkyung Lee، نويسنده , , Hyunsuk Lee، نويسنده , , Kyu Yang Yi، نويسنده , , Byung-Ho Lee، نويسنده , , Sung-eun Yoo، نويسنده , , Kyunghee Lee، نويسنده , , Nam Sook Cho، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2998
To page
3001
Abstract
A series of 4-substituted (benzo[b]thiophene-2-carbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardioprotective efficacy both in vitro and in vivo. Several analogs exhibited a strong inhibition on NHE-1, and which was generally well correlated with their cardioprotective efficacy. Especially the 4-nitro 20 and cyano 50 compounds excellently improved the cardiac function and reduced infarct size against ischemia/reperfusion injury.
Keywords
Cardioprotective , Sodium hydrogen exchanger
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795713
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