Author/Authors :
Pauline C. Ting، نويسنده , , Shelby P. Umland، نويسنده , , Robert Aslanian، نويسنده , , Jianhua Cao، نويسنده , , Charles G. Garlisi، نويسنده , , Ying Huang، نويسنده , , James Jakway، نويسنده , , Zhidan Liu، نويسنده , , Himanshu Shah، نويسنده , , Fang Tian، نويسنده , , Yuntao Wan، نويسنده , , Neng-Yang Shih، نويسنده ,
Abstract :
Structure–activity relationship study of bipiperidine amide 1 has identified the reverse bipiperidine amide 4a as a CC chemokine-3 (CCR3) receptor antagonist. Optimization of the structure–activity relationship of compound 4a has resulted in the identification of a CCR3 antagonist 4i as well as a CCR3 agonist 13.
