Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones
Author/Authors :
Robert E. McDevitt، نويسنده , , Michael S. Malamas، نويسنده , , Eric S. Manas، نويسنده , , Rayomand J. Unwalla and William S. Somers، نويسنده , , Zhang B. Xu، نويسنده , , Chris P. Miller، نويسنده , , Heather A. Harris، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
6
From page :
3137
To page :
3142
Abstract :
The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERβ and ERα are described. Several compounds exhibited high potency and moderate selectivity for the ERβ receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
