Title of article
6-(2-Phenylethyl)nicotine: A novel nicotinic cholinergic receptor ligand
Author/Authors
Anna Ramunno، نويسنده , , Malgorzata Dukat، نويسنده , , Mase Lee، نويسنده , , Richard Young، نويسنده , , Mohamed El-Zahabi، نويسنده , , M. Imad Damaj، نويسنده , , Billy Martin، نويسنده , , Richard A. Glennon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3237
To page
3240
Abstract
6-(2-Phenylethyl)nicotine (1b; Ki = 15 nM) was unexpectedly found to bind at α4β2 nicotinic cholinergic (nACh) receptors. Although this compound failed to produce nicotine-like agonist action in several functional assays, 1b antagonized the antinociceptive effects of nicotine (mouse tail-flick assay) in a dose-dependent fashion when administered via an intrathecal route.
Keywords
nACh receptors , Antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795763
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