Author/Authors :
Kouji Hattori، نويسنده , , Fujiko Takamura، نويسنده , , Akira Tanaka، نويسنده , , Hisashi Takasugi، نويسنده , , Kiyoshi Taniguchi، نويسنده , , Mie Nishio، نويسنده , , Satoshi Koyama، نويسنده , , Jiro Seki، نويسنده , , Kazuo Sakane، نويسنده ,
Abstract :
A metabolism study of FR181157 (1) led to the discovery of new oxazole derivatives as active metabolites. The metabolite 6 with an epoxy ring exhibited high anti-aggregative potency with an IC50 of 5.8 nM and potent binding affinity for the human recombinant IP receptor with a Ki value of 6.1 nM and selectivity for human IP receptor over all other members of the human prostanoid receptor family.
