Title of article
Synthesis and biological evaluation of quinoxaline-5,8-diones that inhibit vascular smooth muscle cell proliferation
Author/Authors
Hwa-Jin Chung، نويسنده , , Ok-Jai Jung، نويسنده , , Mi Jin Chae، نويسنده , , Sung-Yu Hong، نويسنده , , Kwang-Hoe Chung، نويسنده , , Sang Kook Lee، نويسنده , , Chung-Kyu Ryu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
3380
To page
3384
Abstract
A series of 6-arylamino-2,3-bis(pyridin-2-yl)-7-chloro-quinoxaline-5,8-diones were synthesized and evaluated for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. The quinoxaline-5,8-diones exhibited a potent antiproliferative activity. Further mechanistic study revealed that the inhibitory effect of one representative quinoxaline-5,8-dione on SMC proliferation was mediated by modulation of the extracellular signal-regulated kinase 1/2 signaling pathway in the RAoSMCs.
Keywords
Quinoxaline-5 , 8-dione , Smooth muscle cell , ERK1/2 , antiproliferative activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795794
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