Title of article :
(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Further optimisation as highly potent and selective MSK-1-inhibitors
Author/Authors :
Mark J. Bamford، نويسنده , , Nicholas Bailey، نويسنده , , Susannah Davies، نويسنده , , David K. Dean، نويسنده , , Leann Francis، نويسنده , , Terence A. Panchal، نويسنده , , Christopher A. Parr، نويسنده , , Sanjeet Sehmi، نويسنده , , Jon G. Steadman، نويسنده , , Andrew K. Takle، نويسنده , , James T. Townsend، نويسنده , , David M. Wilson III، نويسنده ,
Abstract :
The novel imidazo[4,5-c]pyridine 1,2,5-oxadiazol-3-yl template affords an excellent start point for identification of inhibitors of a number of protein kinases. Here we report on its optimisation for mitogen and stress-activated protein kinase-1 (MSK-1) inhibitory activity, and selectivity over other kinases.
