Title of article
Structure–activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor
Author/Authors
Joseph A. Tran، نويسنده , , Joseph Pontillo، نويسنده , , Melissa Arellano، نويسنده , , Beth A. Fleck، نويسنده , , Fabio C. Tucci، نويسنده , , Dragan Marinkovic، نويسنده , , Caroline W. Chen، نويسنده , , John Saunders، نويسنده , , Alan C. Foster، نويسنده , , Chen Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
3434
To page
3438
Abstract
A series of cyclohexylpiperazines was synthesized as potent and selective antagonists of the human MC4 receptor. Compound 14t displayed binding affinity (Ki) of 4.2 and 1100 nM at MC4R and MC3R, respectively.
Keywords
Melanocortin-4 receptor , Cyclohexylpiperazine , Antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795806
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