Author/Authors :
Lieven Meerpoel، نويسنده , , Jef Van Gestel، نويسنده , , Frans Van Gerven، نويسنده , , Filip Woestenborghs، نويسنده , , Patrick Marichal، نويسنده , , Vic Sipido، نويسنده , , Gilkerson Terence، نويسنده , , Roger Nash، نويسنده , , David Corens، نويسنده , , Ray D. Richards، نويسنده ,
Abstract :
Broad screening revealed compound 1a to be a novel anti-fungal agent with high specificity towards dermatophytes. The anti-fungal structure–activity relationship of this novel class of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines is described together with its mode of action that appeared to be the inhibition of squalene epoxidase. Preliminary in vivo results of the most active compounds are also reported.
